RealNow™ Clinical Evidence

In 174 retrospectively selected acute-stroke cases, RealNow™, RAPID and ShuKun automated ASPECTS were compared with radiologist consensus based on diffusion-weighted MRI. RealNow™’s total-score agreement with the reference was ICC 0.60, and its reported AUC was 0.67; regional agreement varied.

Evidence scope: Retrospective, single-center comparison with modest agreement and variable regional performance. The study does not establish universal superiority, equivalence in every case or improved patient outcomes; clinician image review remains essential.

European Journal of Radiology. 2024;175:111435.

DOI: 10.1016/j.ejrad.2024.111435

In 594 acute ischemic stroke cases, RealNow™ and RAPID were compared on CT or MR perfusion core and penumbra volumes and imaging-based thrombectomy eligibility. Volume ICCs ranged from 0.87 to 0.99; triage decisions agreed in 159/174 CT cases and 400/420 MR cases.

Evidence scope: A retrospective software-comparison study. Volume agreement does not ensure identical triage for every patient or demonstrate improved functional outcomes. Acquisition, thresholds and clinical review remain relevant.

Cells. 2022;11(16):2547.

DOI: 10.3390/cells11162547

DEFUSE 3 studied thrombectomy in patients selected using perfusion imaging. It explains the clinical context for core, penumbra and mismatch measurements.

Evidence scope: An independent treatment trial using its specified imaging-selection workflow. It is not a RealNow™ regulatory approval or direct validation study.

DOI: 10.1056/NEJMoa1713973